Characterization of MYC Translocations in Multiple Myeloma Cell Lines
نویسندگان
چکیده
منابع مشابه
Characterization of MYC translocations in multiple myeloma cell lines.
Translocations involving an MYC gene (c >> N >>L) are very late tumor progression events and provide a paradigm for secondary translocations in multiple myeloma. Using a combination of fluorescent in situ hybridization and comparative genomic hybridization arrays (aCGH), we have identified rearrangements of an MYC gene in 40 of 43 independent myeloma cell lines. A majority of MYC translocations...
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In multiple myeloma, c-MYC is activated and contributes to the malignant phenotype. Targeting MYC by short hairpin RNA induced cell death in myeloma cell lines; however, cell lines are generated from samples taken in advanced stages of the disease and may not reflect patient cells adequately. In this study, we used the selective small molecule inhibitor of MYC-MAX heterodimerization, 10058-F4, ...
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ژورنال
عنوان ژورنال: JNCI Monographs
سال: 2008
ISSN: 1052-6773,1745-6614
DOI: 10.1093/jncimonographs/lgn011